Feuer G., de la Iglesia F.A. Molecular Biochemistry of Human Diseases. Vol. II

Boca Raton: CRC Press, 2019 — 258 p.First published in 1986: This book is to help medical, pharmacy, and advanced students in science to understand the growing importance of continuously advancing biochemical concepts in human disease.Preface
The Authors
Introduction
Basic Reference Books
Dedication
Abnormalities of Water and Electrolyte Metabolism
Introduction
Water Metabolism
Content
Metabolism and Regulation
Sodium Metabolism
Potassium Metabolism
Acid-Base Metabolism
Intracellular Hydrogen Ion Concentration
Hydrogen Ion Balance
Respiratory Acidosis and Alkalosis
Metabolic Acidosis
Metabolic Alkalosis
Calcium Metabolism
Magnesium Metabolism
Phosphate Metabolism
Regulation of Calcium, Magnesium, and Phosphate Metabolism
Assessment of Disturbed Metabolism
References
Further Reading
Abnormalities of Trace Element Metabolism
Introduction
Effect of Environment and Homeostasis
Teratologic Effects
Effects on Endocrine Organs
Effects on Infectious Diseases
Effects on Cellular Membranes
Diseases Associated with Selected Elements
Iron
Copper
Zinc
Manganese
Chromium
Selenium
Mercury
Lead
Cobalt
Nickel
Cadmium
Molybdenum
References
Further Reading
Abnormalities of Cellular Organization
Introduction
Membrane Structure
General
Cytoskeletal Membrane System
Membrane Composition
Proteins
General
Molecular Organization of Membrane Proteins
Lipids
General
Molecular Organization of Membrane Lipids
Phospholipids
Steroids
Glycolipids
Membrane Abnormalities in Cell Injury
Diseases of Membrane Transport Mechanism
Active Transport
Epithelial Transport
Diseases of Disturbed Transport
Hypophosphatemia
Tubular Reabsorption Defects
Membrane Abnormalities in Neurological Disorders
Synaptic Transmission Abnormalities
Excitable Membrane Abnormalities
Membrane Abnormalities in Metabolic Disorders
Brush Border Membrane Disorders
Carbohydrate-Related Abnormalities
Amino Acid- and Protein-Related Abnormalities
Renal Tubular Abnormalities
Secondary Brush Border Membrane Disorders
Platelet Membranes
Membrane Surface Receptors
Regulation and Disease
Role in Carcinogenesis
Subcellular Organelles
Nucleus
Mitochondria
Ischemic Injury
Toxic Injury
Genetic Diseases
Lysosomes
Thyroid Lysosomes in Disease
Lysosomotropic Effects
Endoplasmic Reticulum
Changes in Diseases
Protein Synthesis
Drug Metabolism
Metabolism of Body Constituents
Response to Toxic Compounds
Enzyme Induction
Enzyme Induction during Development
Enzyme Induction and Drug Metabolism
Clinical Importance of Enzyme Induction
Adverse Effects of Enzyme Induction
Enzyme Induction and Toxic Actions
Enzyme Induction and Gene Regulation
Enzyme Induction and Carcinogenesis
Golgi Apparatus
Carcinogenesis and Cellular Organelles
Structural Changes
Interactions with Nuclear Components
Interrelationship Between Cellular Organelles
Cell Shape Abnormalities
Erythrocyte Disorders
Deformation of Erythrocyte Shape
Hereditary Erythrocyte Disorders
Hemoglobinopathies Affecting Membrane Structure
Enzyme Deficiencies in Erythrocytes
Muscular Dystrophy
Radiation Effects on Biomembranes
Effects of Exposure
Molecular Mechanisms of Radiation Damage
Protein Damage
Lipid Damage
Sugar Radiolysis
Effects on Membranes
Damage of Membrane Function
References
Further Reading
Glossary
Appendix: The International System of Units
Index