Bonucci E. Biological Calcification: Normal and Pathological Processes in the Early Stages

Springer, 2007. — 599 p. — ISBN13: 978-3-540-36012-4.This book follows a precursor volume devoted to biological calci?cation, - sued by the CRC Press, Boca Raton (Florida) in 1992. Several basic aspects of the calci?cation process were analyzed in it by outstanding authors who had unquestioned competence in their respective research areas. Its main aim was that of giving readers access to a series of papers which, even though they discussed divergent aspects of biological calci?cations drawn from the study of systems as different as vertebrate skeletons and mollusks, in vitro cultures and unicellular organisms, ectopic calci?cation and urinary stones, provided elements permitting a coherent approach to a comprehensive view of the calci?cation process in biological tissues. Now, almost 15 years after the publication of that book, a great variety of new data from a wide spectrum of biological organisms and systems has enriched our knowledge of the normal and pathological mechanisms which can lead to calci?cation. Even so, this whole process is still problematic: the new knowledge, concepts and ideas have often suggested that a de?nitive solution was close at hand, but the local mechanism through which the inorganic substance is laid down in organic matrices continues to be an elusive, largely enigmatic topic.Historical Notes
Methodology
The Nature and Composition of the Inorganic Phase
The Shape of Inorganic Particles
The Size of Inorganic Particles
Calcifying Matrices: Bone and Tendons
Calcifying Matrices: Dentin and Cementum
Calcifying Matrices: Cartilage
Calcifying Matrices: Enamel
Calcifying Matrices: Lower Vertebrates
Calcifying Matrices: Invertebrates
Calcifying Matrices: Non-skeletal Structures
Calcifying Matrices: Pathological Calcifications
Calcifying Matrices: Acquired or Experimental Diseases; Heritable Disorders; Genetically Modified Animals
The Organic-inorganic Relationships in Calcifying Matrices
Main Suggested Calcification Mechanisms: Cells
Main Suggested Calcification Mechanisms: Extracellular Matrix
Conclusions